Anti-COCH Polyclonal Antibody
品牌：solarbio | 货号：K004616P
| 英文名称 | Anti-COCH Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | COCH-5B2;COCH5B2;DFNA9 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. IF 1:50-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 59kDa |
| Gene ID | 1690 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human COCH |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human COCH |
| Subcellular Locations | Secreted extracellular matrix extracellular space |
| Swiss Prot | O43405 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. |