Anti-PPM1A Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-PPM1A Polyclonal Antibody

品牌:solarbio | 货号:K004723P

英文名称 Anti-PPM1A Polyclonal Antibody
宿主 Rabbit
别名 PP2C-ALPHA;PP2CA;PP2Calpha
应用 WB IF
稀释比例 WB 1:500-2000. IF 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 42kDa
Gene ID 5494
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human PPM1A
性状 液体
Public Immunogen Range Recombinant protein of human PPM1A
Subcellular Locations Cytoplasm Lipid-anchor Membrane Nucleus cytosol
Swiss Prot P35813
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.