Anti-PPM1A Polyclonal Antibody
品牌:solarbio | 货号:K004723P
英文名称 |
Anti-PPM1A Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
PP2C-ALPHA;PP2CA;PP2Calpha |
应用 |
WB IF |
稀释比例 |
WB 1:500-2000. IF 1:50-200. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
42kDa |
Gene ID |
5494 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human PPM1A |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human PPM1A |
Subcellular Locations |
Cytoplasm Lipid-anchor Membrane Nucleus cytosol |
Swiss Prot |
P35813 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |