Anti-FAS Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-FAS Polyclonal Antibody

品牌:solarbio | 货号:K000322P

英文名称 Anti-FAS Polyclonal Antibody
宿主 Rabbit
别名 ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-100.
蛋白分子量 38kDa
Gene ID 355
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human FAS
性状 液体
Public Immunogen Range A synthetic peptide of human FAS
Subcellular Locations Cell membrane Secreted Single-pass type I membrane protein
Swiss Prot P25445
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.