Anti-COMT Polyclonal Antibody
品牌：solarbio | 货号：K004363P
| 英文名称 | Anti-COMT Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HEL-S-98n |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 30kDa |
| Gene ID | 1312 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human COMT |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human COMT |
| Subcellular Locations | Cell membrane Cytoplasm Extracellular side Single-pass type II membrane protein |
| Swiss Prot | P21964 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. |