Anti-TNFSF12 Polyclonal Antibody
品牌:solarbio | 货号:K004114P
英文名称 |
Anti-TNFSF12 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
APO3L;DR3LG;TNLG4A;TWEAK |
应用 |
WB IHC |
稀释比例 |
WB 1:500-2000. IHC 1:50-200. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
27kDa |
Gene ID |
8742 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human TNFSF12 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human TNFSF12 |
Subcellular Locations |
Cell membrane Secreted Single-pass membrane protein Single-pass type II membrane protein |
Swiss Prot |
O43508 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. |