Anti-HUS1 Polyclonal Antibody
品牌：solarbio | 货号：K003976P
| 英文名称 | Anti-HUS1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | hHUS1 |
| 应用 | WB IF IP |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. IP 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 32kDa |
| Gene ID | 3364 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human HUS1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human HUS1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | O60921 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. |