Anti-ACVR2B Polyclonal Antibody
品牌：solarbio | 货号：K008109P
| 英文名称 | Anti-ACVR2B Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HTX4;ACTRIIB;ActR-IIB |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 58kDa |
| Gene ID | 93 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ACVR2B |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ACVR2B |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q13705 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |