Anti-ACVR2B Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-ACVR2B Polyclonal Antibody

品牌:solarbio | 货号:K008109P

英文名称 Anti-ACVR2B Polyclonal Antibody
宿主 Rabbit
别名 HTX4;ACTRIIB;ActR-IIB
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 58kDa
Gene ID 93
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human ACVR2B
性状 液体
Public Immunogen Range Recombinant protein of human ACVR2B
Subcellular Locations Cytoplasm
Swiss Prot Q13705
克隆类型 Polyclonal Antibody
背景资料 Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.