Anti-XIAP Polyclonal Antibody
品牌：solarbio | 货号：K004828P
| 英文名称 | Anti-XIAP Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | API3;BIRC4;IAP-3;ILP1;MIHA;XLP2;hIAP-3;hIAP3 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. IF 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 57kDa |
| Gene ID | 331 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human XIAP |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human XIAP |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P98170 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11. |