Anti-PLOD2 Polyclonal Antibody
品牌：solarbio | 货号：K004884P
| 英文名称 | Anti-PLOD2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BRKS2;LH2;TLH |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. |
| 交叉反应 | Human Rat |
| 蛋白分子量 | 85kDa |
| Gene ID | 5352 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PLOD2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PLOD2 |
| Subcellular Locations | Lumenal side Peripheral membrane protein Rough endoplasmic reticulum membrane |
| Swiss Prot | O00469 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |