Anti-PLOD2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-PLOD2 Polyclonal Antibody

品牌:solarbio | 货号:K004884P

英文名称 Anti-PLOD2 Polyclonal Antibody
宿主 Rabbit
别名 BRKS2;LH2;TLH
应用 WB IF
稀释比例 WB 1:500-2000. IF 1:50-100.
交叉反应 Human Rat
蛋白分子量 85kDa
Gene ID 5352
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human PLOD2
性状 液体
Public Immunogen Range Recombinant protein of human PLOD2
Subcellular Locations Lumenal side Peripheral membrane protein Rough endoplasmic reticulum membrane
Swiss Prot O00469
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.