Anti-PMS2 Polyclonal Antibody
品牌：solarbio | 货号：K004885P
| 英文名称 | Anti-PMS2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HNPCC4;MLH4;PMS2CL;PMSL2 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 96kDa |
| Gene ID | 5395 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PMS2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PMS2 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P54278 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. |