Anti-CBFA2T2 Polyclonal Antibody
品牌：solarbio | 货号：K004956P
| 英文名称 | Anti-CBFA2T2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | EHT;MTGR1;ZMYND3;p85 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 67kDa |
| Gene ID | 9139 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CBFA2T2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CBFA2T2 |
| Subcellular Locations | Nucleus |
| Swiss Prot | O43439 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5′-region of the RUNX1 (AML1) gene fused to the 3′-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. |