Anti-RBP3 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-RBP3 Polyclonal Antibody

品牌:solarbio | 货号:K004498P

英文名称 Anti-RBP3 Polyclonal Antibody
宿主 Rabbit
别名 D10S64;D10S65;D10S66;IRBP;RBPI;RP66
应用 WB IF
稀释比例 WB 1:500-2000. IF 1:50-100.
交叉反应 Human Mouse Rat
蛋白分子量 135kDa
Gene ID 5949
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human RBP3
性状 液体
Public Immunogen Range Recombinant protein of human RBP3
Subcellular Locations Secreted extracellular matrix extracellular space interphotoreceptor matrix
Swiss Prot P10745
克隆类型 Polyclonal Antibody
背景资料 Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.