Anti-ERCC1 Polyclonal Antibody
品牌：solarbio | 货号：K007960P
| 英文名称 | Anti-ERCC1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | UV20;COFS4;RAD10 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 33kDa |
| Gene ID | 2067 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human ERCC1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human ERCC1 |
| Swiss Prot | P07992 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5′ incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. |