Anti-IL10 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-IL10 Polyclonal Antibody

品牌:solarbio | 货号:K009382P

英文名称 Anti-IL10 Polyclonal Antibody
宿主 Rabbit
别名 IL10;CSIF;GVHDS;IL-10;IL10A;TGIF;interleukin-10
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-100.
交叉反应 Human Mouse Rat
蛋白分子量 20kDa
Gene ID 3586
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human IL10
性状 液体
Public Immunogen Range Recombinant protein of human IL10
Subcellular Locations Secreted
Swiss Prot P22301
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.