Anti-IL10 Polyclonal Antibody
品牌:solarbio | 货号:K009382P
英文名称 |
Anti-IL10 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
IL10;CSIF;GVHDS;IL-10;IL10A;TGIF;interleukin-10 |
应用 |
WB IHC |
稀释比例 |
WB 1:500-2000. IHC 1:50-100. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
20kDa |
Gene ID |
3586 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human IL10 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human IL10 |
Subcellular Locations |
Secreted |
Swiss Prot |
P22301 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |