Anti-ZAP-70 Monoclonal Antibody
品牌：solarbio | 货号：K007477P
| 英文名称 | Anti-ZAP-70 Monoclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | SRK;STD;TZK;STCD;IMD48;ADMIO2;ZAP-70 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-300. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 70kDa |
| Gene ID | 7535 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ZAP70 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ZAP70 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P43403 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. |