Anti-CALR Polyclonal Antibody
品牌：solarbio | 货号：K008162P
| 英文名称 | Anti-CALR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | RO;CRT;SSA;cC1qR |
| 应用 | WB IHC |
| 稀释比例 | WB 1:1000-5000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 48kDa |
| Gene ID | 811 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CALR |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CALR |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P27797 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. |