Anti-BAG3 Polyclonal Antibody
品牌：solarbio | 货号：K008088P
| 英文名称 | Anti-BAG3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BIS;MFM6;BAG-3;CAIR-1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:40-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 62kDa |
| Gene ID | 9531 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human BAG3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human BAG3 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | O95817 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. |