Anti-RAD50 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-RAD50 Polyclonal Antibody

品牌:solarbio | 货号:K007557P

英文名称 Anti-RAD50 Polyclonal Antibody
宿主 Rabbit
别名 NBSLD;RAD502;hRad50
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 154kDa
Gene ID 10111
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human RAD50
性状 液体
Public Immunogen Range A synthetic peptide of human RAD50
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q92878
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.