Anti-CCND1 Polyclonal Antibody
品牌：solarbio | 货号：K007413P
| 英文名称 | Anti-CCND1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BCL1;PRAD1;U21B31;D11S287E |
| 应用 | IHC |
| 稀释比例 | IHC 1:10-50. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 34kDa |
| Gene ID | 595 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CCND1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CCND1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P24385 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |