Anti-CX3CL1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CX3CL1 Polyclonal Antibody

品牌:solarbio | 货号:K007410P

英文名称 Anti-CX3CL1 Polyclonal Antibody
宿主 Rabbit
别名 NTN;NTT;CXC3;CXC3C;SCYD1;ABCD-3;C3Xkine;fractalkine;neurotactin
应用 IHC
稀释比例 IHC 1:25-100.
交叉反应 Human Mouse Rat
蛋白分子量 42kDa
Gene ID 6376
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human CX3CL1
性状 液体
Public Immunogen Range A synthetic peptide of human CX3CL1
Subcellular Locations Cell membrane Cytoplasm
Swiss Prot P78423
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice).The polypeptide structure of CXC3L1 differs from the typical structure of other chemokines.CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. However a soluble (90 kD) version of this chemokine has also been observed. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed. CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22.