Anti-CYFIP2 Polyclonal Antibody
品牌：solarbio | 货号：K007003P
| 英文名称 | Anti-CYFIP2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | PIR121 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 148kDa |
| Gene ID | 26999 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CYFIP2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CYFIP2 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q96F07 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. |