Anti-Phospho-RAF1-S259 Polyclonal Antibody
品牌：solarbio | 货号：K006222P
| 英文名称 | Anti-Phospho-RAF1-S259 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CMD1NN;CRAF;NS5;Raf-1;c-Raf |
| 应用 | WB IP |
| 稀释比例 | WB 1:500-2000. IP 1:50-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 73kDa |
| Gene ID | 5894 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding S259 of human RAF1 |
| 性状 | 液体 |
| Public Immunogen Range | A phospho specific peptide corresponding to residues surrounding S259 of human RAF1 |
| Subcellular Locations | Cell membrane Cytoplasm Mitochondrion Nucleus |
| Swiss Prot | P04049 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. |