Anti-GNE Polyclonal Antibody
品牌：solarbio | 货号：K005920P
| 英文名称 | Anti-GNE Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DMRV;GLCNE;IBM2;NM;Uae1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 79kDa |
| Gene ID | 10020 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human GNE |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human GNE |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9Y223 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. |