Anti-SHC1 Polyclonal Antibody
品牌：solarbio | 货号：K005417P
| 英文名称 | Anti-SHC1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | SHC;SHCA |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 63kDa |
| Gene ID | 6464 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human SHC1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human SHC1 |
| Subcellular Locations | Cytoplasm Mitochondrion Mitochondrion matrix |
| Swiss Prot | P29353 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. |