Anti-NOTCH1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-NOTCH1 Polyclonal Antibody

品牌:solarbio | 货号:K005358P

英文名称 Anti-NOTCH1 Polyclonal Antibody
宿主 Rabbit
别名 AOS5;AOVD1;TAN1;hN1
应用 WB IHC IF
稀释比例 WB 1:500-2000. IHC 1:100-200. IF 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 273kDa
Gene ID 4851
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human NOTCH1
性状 液体
Public Immunogen Range A synthetic peptide of human NOTCH1
Subcellular Locations Cell membrane Nucleus Single-pass type I membrane protein
Swiss Prot P46531
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.