Anti-BMPR2 Polyclonal Antibody
品牌：solarbio | 货号：K004120P
| 英文名称 | Anti-BMPR2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BMPR-II;BMPR3;BMR2;BRK-3;POVD1;PPH1;T-ALK |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 115kDa |
| Gene ID | 659 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human BMPR2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human BMPR2 |
| Subcellular Locations | Cell membrane Single-pass type I membrane protein |
| Swiss Prot | Q13873 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. |