Anti-ABAT Polyclonal Antibody
品牌：solarbio | 货号：K003895P
| 英文名称 | Anti-ABAT Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GABA-AT;GABAT;NPD009 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 56kDa |
| Gene ID | 18 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ABAT |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ABAT |
| Subcellular Locations | Mitochondrion matrix |
| Swiss Prot | P80404 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |