Anti-CALM2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CALM2 Polyclonal Antibody

品牌:solarbio | 货号:K005618P

英文名称 Anti-CALM2 Polyclonal Antibody
宿主 Rabbit
别名 CAMII;LQT15;PHKD;PHKD2;caM
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Human Mouse Rat
蛋白分子量 17kDa
Gene ID 805
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human CALM2
性状 液体
Public Immunogen Range Recombinant protein of human CALM2
Subcellular Locations Cytoplasm cytoskeleton spindle spindle pole
Swiss Prot P62158
克隆类型 Polyclonal Antibody
背景资料 This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.