Anti-CBX4 Polyclonal Antibody
品牌：solarbio | 货号：K004048P
| 英文名称 | Anti-CBX4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | NBP16;PC2 |
| 应用 | WB IP |
| 稀释比例 | WB 1:500-2000. IP 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 61kDa |
| Gene ID | 8535 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CBX4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CBX4 |
| Subcellular Locations | Nucleus Nucleus speckle |
| Swiss Prot | O00257 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. CBX4 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development . |