Anti-C5 Polyclonal Antibody
品牌：solarbio | 货号：K005658P
| 英文名称 | Anti-C5 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | C5D;C5a;C5b;CPAMD4;ECLZB |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. IF 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 188kDa |
| Gene ID | 727 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human C5 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human C5 |
| Subcellular Locations | Secreted |
| Swiss Prot | P01031 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. |