Anti-HIRA Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-HIRA Polyclonal Antibody

品牌:solarbio | 货号:K005855P

英文名称 Anti-HIRA Polyclonal Antibody
宿主 Rabbit
别名 DGCR1;TUP1;TUPLE1
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:100-200.
交叉反应 Human Mouse
蛋白分子量 112kDa
Gene ID 7290
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human HIRA
性状 液体
Public Immunogen Range Recombinant protein of human HIRA
Subcellular Locations Nucleus PML body
Swiss Prot P54198
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.