Anti-HIRA Polyclonal Antibody
品牌：solarbio | 货号：K005855P
| 英文名称 | Anti-HIRA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DGCR1;TUP1;TUPLE1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:100-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 112kDa |
| Gene ID | 7290 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human HIRA |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human HIRA |
| Subcellular Locations | Nucleus PML body |
| Swiss Prot | P54198 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. |