Anti-CACNA2D2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CACNA2D2 Polyclonal Antibody

品牌:solarbio | 货号:K007989P

英文名称 Anti-CACNA2D2 Polyclonal Antibody
宿主 Rabbit
别名 CACNA2D
应用 IHC
稀释比例 IHC 1:30-150.
交叉反应 Human Mouse Rat
蛋白分子量 130/122kDa
Gene ID 9254
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human CACNA2D2
性状 液体
Public Immunogen Range A synthetic peptide of human CACNA2D2
Subcellular Locations Membrane
Swiss Prot Q9NY47
克隆类型 Polyclonal Antibody
背景资料 Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.?