Anti-CACNA2D2 Polyclonal Antibody
品牌:solarbio | 货号:K007989P
英文名称 |
Anti-CACNA2D2 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CACNA2D |
应用 |
IHC |
稀释比例 |
IHC 1:30-150. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
130/122kDa |
Gene ID |
9254 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human CACNA2D2 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human CACNA2D2 |
Subcellular Locations |
Membrane |
Swiss Prot |
Q9NY47 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.? |