Anti-ADAM10 Polyclonal Antibody
品牌：solarbio | 货号：K008282P
| 英文名称 | Anti-ADAM10 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | kuz;AD10;MADM;CD156c;HsT18717 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 84kDa |
| Gene ID | 102 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ADAM10 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ADAM10 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | O14672 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77′ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). |