Anti-ACTN4 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-ACTN4 Polyclonal Antibody

品牌:solarbio | 货号:K008357P

英文名称 Anti-ACTN4 Polyclonal Antibody
宿主 Rabbit
别名 FSGS;FSGS1;ACTININ-4
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 105kDa
Gene ID 81
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human ACTN4
性状 液体
Public Immunogen Range Recombinant protein of human ACTN4
Subcellular Locations Cytoplasm
Swiss Prot O43707
克隆类型 Polyclonal Antibody
背景资料 Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.