Anti-ACTN4 Polyclonal Antibody
品牌:solarbio | 货号:K008357P
英文名称 |
Anti-ACTN4 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
FSGS;FSGS1;ACTININ-4 |
应用 |
WB IHC |
稀释比例 |
WB 1:500-2000. IHC 1:50-200. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
105kDa |
Gene ID |
81 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human ACTN4 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human ACTN4 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
O43707 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. |