Anti-MOG?Polyclonal?Antibody-一抗-抗体-蛋白与免疫

Anti-MOG?Polyclonal?Antibody

品牌:solarbio | 货号:K009386P

英文名称 Anti-MOG?Polyclonal?Antibody
宿主 Rabbit
别名 MOG(35-55);myelin oligo-dendrocyte glycoprotein-MOG;MGC26137;MOG alpha 6;MOG;MOGIG2;Myelin oligodendrocyte glycoprotein;
应用 WB ELISA IHC-P IHC-F ICC IF
稀释比例 WB 1:500-2000.?ELISA 1:500-1000.?IHC-P 1:400-800.?IHC-F 1:400-800.?ICC 1:100-500.?IF 1:100-500
交叉反应 Human?Mouse?Rat?Pig
蛋白分子量 24kDa
Gene ID 4340
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of mouse MOG
性状 液体
Public Immunogen Range A synthetic peptide of mouse MOG
Subcellular Locations Cytomembrane
Swiss Prot Q61885
克隆类型 Polyclonal Antibody
背景资料 The protein is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG’s possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.