Anti-NUDT1 Polyclonal Antibody
品牌：solarbio | 货号：K004021P
| 英文名称 | Anti-NUDT1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | MTH1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 23kDa |
| Gene ID | 4521 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human NUDT1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human NUDT1 |
| Subcellular Locations | Cytoplasm Mitochondrion matrix Nucleus |
| Swiss Prot | P36639 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. |