Anti-ING3 Polyclonal Antibody
品牌：solarbio | 货号：K004241P
| 英文名称 | Anti-ING3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Eaf4;ING2;MEAF4;p47ING3 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 47kDa |
| Gene ID | 54556 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ING3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ING3 |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q9NXR8 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. |