Anti-DUSP1 Polyclonal Antibody
品牌：solarbio | 货号：K003533P
| 英文名称 | Anti-DUSP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CL100;HVH1;MKP-1;MKP1;PTPN10 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 39kDa |
| Gene ID | 1843 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human DUSP1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human DUSP1 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P28562 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. |