Anti-MCM4 Polyclonal Antibody
品牌：solarbio | 货号：K003557P
| 英文名称 | Anti-MCM4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CDC21;CDC54;NKCD;NKGCD;P1-CDC21;hCdc21 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 97kDa |
| Gene ID | 4173 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human MCM4 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human MCM4 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P33991 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. |