Anti-LEPR Polyclonal Antibody
品牌：solarbio | 货号：K003552P
| 英文名称 | Anti-LEPR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CD295;LEP-R;LEPRD;OB-R;OBR |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human |
| 蛋白分子量 | 132kDa |
| Gene ID | 3953 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human LEPR |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human LEPR |
| Subcellular Locations | Cell membrane Secreted Single-pass type I membrane protein |
| Swiss Prot | P48357 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). |