Anti-PDHA1 Polyclonal Antibody
品牌：solarbio | 货号：K007472P
| 英文名称 | Anti-PDHA1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | PDHA;PDHAD;PHE1A;PDHCE1A |
| 应用 | WB IHC |
| 稀释比例 | WB 1:1000-5000. IHC 1:50-300. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 43kDa |
| Gene ID | 5160 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PDHA1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PDHA1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P08559 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |