Anti-ADIPOR1 Polyclonal Antibody
品牌：solarbio | 货号：K106516P
| 英文名称 | Anti-ADIPOR1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CGI-45;CGI45;PAQR1;TESBP1A |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 45kDa |
| Gene ID | 51094 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human ACDCR1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human ACDCR1 |
| Subcellular Locations | Cell membrane |
| Swiss Prot | Q96A54 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. |