Anti-GRK4 Polyclonal Antibody
品牌：solarbio | 货号：K008161P
| 英文名称 | Anti-GRK4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | IT11;GPRK4;GRK4a;GPRK2L |
| 应用 | WB IHC |
| 稀释比例 | WB 1:1000-5000. IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 67kDa |
| Gene ID | 2868 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human GRK4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human GRK4 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P32298 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. |