Anti-HSD17B1 Polyclonal Antibody
品牌：solarbio | 货号：K007732P
| 英文名称 | Anti-HSD17B1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HSD17;EDHB17;EDH17B2;SDR28C1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 35kDa |
| Gene ID | 3292 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human HSD17B1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human HSD17B1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P14061 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy. |