Anti-HMGCS1 Polyclonal Antibody
品牌：solarbio | 货号：K007722P
| 英文名称 | Anti-HMGCS1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HMGCS |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 57kDa |
| Gene ID | 3157 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human HMGCS1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human HMGCS1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q01581 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4. |