Anti-HMGCS1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-HMGCS1 Polyclonal Antibody

品牌:solarbio | 货号:K007722P

英文名称 Anti-HMGCS1 Polyclonal Antibody
宿主 Rabbit
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human
蛋白分子量 57kDa
Gene ID 3157
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human HMGCS1
性状 液体
Public Immunogen Range A synthetic peptide of human HMGCS1
Subcellular Locations Cytoplasm
Swiss Prot Q01581
克隆类型 Polyclonal Antibody
背景资料 HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.