Anti-PRMT5 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-PRMT5 Polyclonal Antibody

品牌:solarbio | 货号:K007555P

英文名称 Anti-PRMT5 Polyclonal Antibody
宿主 Rabbit
别名 JBP1;SKB1;IBP72;SKB1Hs;HRMT1L5
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:15-50.
交叉反应 Human Mouse Rat
蛋白分子量 71kDa
Gene ID 10419
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human PRMT5
性状 液体
Public Immunogen Range A synthetic peptide of human PRMT5
Subcellular Locations Cytoplasm
Swiss Prot O14744
克隆类型 Polyclonal Antibody
背景资料 Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.