Anti-PRMT5 Polyclonal Antibody
品牌：solarbio | 货号：K007555P
| 英文名称 | Anti-PRMT5 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | JBP1;SKB1;IBP72;SKB1Hs;HRMT1L5 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:15-50. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 71kDa |
| Gene ID | 10419 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human PRMT5 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human PRMT5 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | O14744 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. |