Anti-MAPK8 Polyclonal Antibody
品牌：solarbio | 货号：K007522P
| 英文名称 | Anti-MAPK8 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | JNK;JNK1;PRKM8;SAPK1;JNK-46;JNK1A2;SAPK1c;JNK21B1/2 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Rat |
| 蛋白分子量 | 48kDa |
| Gene ID | 5599 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human MAPK8 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human MAPK8 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P45983 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |