Anti-EEA1 Polyclonal Antibody
品牌：solarbio | 货号：K007365P
| 英文名称 | Anti-EEA1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | MST105;ZFYVE2;MSTP105 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 163kDa |
| Gene ID | 8411 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human EEA1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human EEA1 |
| Subcellular Locations | Endosome |
| Swiss Prot | Q15075 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking. The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes. The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin. Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion. |