Anti-GP1BA Polyclonal Antibody
品牌：solarbio | 货号：K007056P
| 英文名称 | Anti-GP1BA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BSS;GP1B;VWDP;CD42B;GPIbA;BDPLT1;BDPLT3;DBPLT3;CD42b-alpha |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:100-300. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 72kDa |
| Gene ID | 2811 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human GP1BA |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human GP1BA |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P07359 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. |