Anti-DUSP6 Polyclonal Antibody
品牌：solarbio | 货号：K006739P
| 英文名称 | Anti-DUSP6 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | MKP3;PYST1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 27kDa |
| Gene ID | 1848 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human DUSP6 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human DUSP6 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q16828 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.? |